DMSO dimethyl sulfoxide

DMSO, or dimethyl sulfoxide, is a byproduct of paper production. It comes from material found in wood. DMSO has been used as an industrial solvent since the mid-1800s.Approximately since the mid-20th century, researchers have examined its use as an anti-inflammatory substance.The FDA approved DMSO as a prescription drug to treat the symptoms of painful bladder syndrome. It is also used under medical supervision to treat a number of other conditions, including shingles. DMSO is easily absorbed into the skin. It issometimes used to increase the body’s uptake ofother drugs. DMSO is available over-the-counter most often in gel or cream form.Although it can sometimes be found as an ingestible supplement, most often DMSO is mainly used by applying it to the skin.

Why do people use DMSO?

DMSO has been used to try to relieve the pain of osteoarthritis. It is also known as an ” alternative” cancer treatment.

People used it to try to treat wounds, burns and other injuries.People have also used it to try to treat situations such as:

  • headache
  • Rheumatoid arthritis
  • Eye problems
  • Scars
  • Scleroderma (a disease that causes the formation of scar tissue in the skin)

Besides its use as a prescription drug, there is little scientific evidence to support other claims made regarding DMSO efficacy.

The American Cancer Society says there is no evidence to support the use of DMSO inthe treatment of cancer. Using it in this way can cause serious delays in receiving proper and effective treatment.

There are no studies that provide guidelines for determining the correct dosage of DMSO.The gel used to treatosteoarthritisusually has a concentration of 25%.It is applied three or four times a day.But over-the-counter DMSO can range from 10% concentration to 90%.

DMSO can increase the effect of certain medications, which can lead to serious health problems. Do not consume with medications such as:

DMSO is a solvent and when it is on the skin it will cause everything on the skin to be absorbed into the body. So be sure to wash your hands and skin well before use.

Pregnant and lactating women should not use DMSO, as little is known about its possible effects on the fetus or baby.

You also should not use DMSO without talking to your doctor if you have:

Healing Using DMSO – Concentrations

https://www.youtube.com/watch?v=_8lAqayHXXA

DMSO and types of plastics for storage

https://www.youtube.com/watch?v=U8Ut7C7dE30

What is DMSO and what can be done with it?

Wikipedia

Dimethyl sulfoxide(DMSO) is an organosulfur compound with formula(CH3)2SO. An important colorless liquid is an aprotic solvent that dissolves polar polar compound and is contained in a wide variety of organic solvents, as well as water.It has a relatively high boiling point.DMSO has the unusual feature that many people feel a garlic-like taste in their mouths after contact with the skin.[3]

In terms of chemical structure, the molecule has an idealizationoftheCs symmetry. It has atrigonal pyramid and molecular geometrythat coincides with the other three correlate S(IV) compounds,with[4] a pair of nonbonded electronson approximately asulfur atom tetrahedral.

DMSO is used in polymerase chain reaction (PCR) to inhibit secondary structures within the DNA pattern or DNA primers. It is added to the PCR mixture before the reaction, where it interferes with the self-completion of the DNA, minimizing the interfering reactions.

PCR reaction DMSO is applicable for twisted plasmids (to relax before amplification) or DNA patterns with high GC content (to reduce thermonuclear stability). For example, a final concentration of 10% DMSO in a PCR mixture with Phusion reduces the primer annealing temperature (i.e., primer melting temperature) by 5.5-6.0 degrees Celsius (9.9-10.8 degrees Fahrenheit). [23]

Known as the arrest of reversible cell cycle in stage G1 of human lymphoid cells. [24]

DMSO may also be used as a cryopreservation agent, when added to the cell’s media to reduce ice formation and thus prevent cell death during the freezing process. [25] Approximately 10% can be used in a slow-freezing method, and cells can be frozen at 80°C (-112°F) or stored safely in liquid nitrogen.

In cell culture, DMSO is used to induce differentiation of P19 embryonic carcinoma cells into cardiomyocytes and skeletal muscle cells.

medicine
The use of DMSO in medicine dates back to around 1963, when the staff of the Oregon University School of Health and Science, led by Stanley Jacob, discovered that it could penetrate the skin and other membranes without damaging them and could carry other compounds to the biological system. In medicine, DMSO is mainly used as a topical analgesic , a vehicle for topical application of medicines, as an anti-inflammatory , and as an antioxidant . [26] Because DMSO increases the rate at which certain compounds are absorbed through biological tissues, including skin, it is used in the administration of drugs through the skin. Systems. Its effect may improve with the addition of EDTA. It is often composed with antifungal drugs, which allow them to penetrate not only the skin but also the nails and nails. [27]

DMSO has been tested to treat many conditions and diseases, but the Food and Drug Administration (FDA) has approved its use only for symptomatic relief of patients with interstitial cystitis . [28] A 1978 study concluded that DMSO produced significant relief for the majority of the 213 patients with studied inflammatory genitourinary disorders. [29] The authors recommended DMSO for genitourinary conditions not caused by an infection or tumor, in which the symptoms were severe or the patients did not respond to conventional treatment.

A gel containing DMSO, dexpanthenol, and heparin, is sold in Germany and Eastern Europe (commercialized under the brand Dolobene [30] ) for topical use in sprains, tendons, and local inflammation. [31]

In interventional radiology , DMSO is used as a solvent for the ethylene vinyl alcohol of the onyx liquid embolism agent, which is used in embolization , therapeutic obstruction of blood vessels.

In cryobiology DMSO has been used as a cryoprotectant and is still an important component of cryoprotectant vitrification mixtures used to preserve organs, tissues, and cell suspensions. Without it, up to 90% of frozen cells will become inactive. Especially important is the freezing and long-term storage of embryonic stem cells and hematopoietic stem cells , which are most often frozen in a mixture of 10% DMSO, a freezing medium, and 30% in bovine serum embryos . In cryogenic freezing of heteroploid cell lines (MDCK, VERO, etc.) a mixture of 10% DMSO with 90% EMEM (70% EMEM + 30% fetal beef serum + antibiotic blend) is used. As part of self-marrow transplantation, DMSO is re-injected along with the patient’s own hematopoietic stem cells.

DMSO is metabolized by disproportionation to dimethylsulfide and dimethylsulfone . It is subjected to renal and lung secretion. A possible side effect of DMSO is therefore increased dimethyl sulfate in the blood, which can cause a symptom of halitosis in the blood . [ צריך ציטוט ]

Alternative medicine
DMSO is marketed as an alternative medicine . Its popularity as an alternative drug is due to a 60-minute documentary with early supports. [32] However, DMSO is an ingredient in some of the products listed by the US FDA as counterfeit cancer [33] drugs and the FDA has waged a fight with distributors. [32] One such distributor is Mildred Miller, who promoted DMSO due to a variety of disorders and was subsequently convicted of Medicare fraud. [32]

The use of DMSO as an alternative treatment for cancer is of particular concern, as it has been shown to intervene with a variety of chemotherapy drugs, including cisplatin , carboplatin , and oxaliplatin . [34] There is not enough evidence to support the hypothesis that DMSO has any effect, and most sources agree that the history of its side effects when testing warrants when using it as a dietary supplement, [35] for which it is heavily marketed with the standard disclaimer.

Veterinary medicine
DMSO is commonly used in veterinary medicine as an ointment for horses , alone or in combination with other ingredients. In the latter case, often, the intended function of DMSO is as a solvent, to carry the rest of the components on the surface of the skin. DMSO is also used intravenously, again alone or in combination with other drugs. It is used alone to treat increased intracranial pressure and/or cerebral edema in horses.

taste
The garlic flavor perceived in skin contact with DMSO may be due to non-fragrant activation of TRPA1 receptors in the trigeminal nuclei. [36] Unlike dimethyl and diallyl disulfide (also with odors similar to garlic), the mono and three sulfides (usually with bad odors), and other similar structures, the pure chemical DMSO is odorless.